Download lagu Lilac Lactulose Syrup.Lilac Syrup is used for Acute constipation. Benefits,Uses,Side Effects,Doses Mp3

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Title:	Lilac Lactulose Syrup.Lilac Syrup is used for Acute constipation. Benefits,Uses,Side Effects,Doses
Contributing Artist:	Treatment With Medicine By Adil
Album:	Lilac Lactulose Syrup.Lilac Syrup is used for Acute constipation. Benefits,Uses,Side Effects,Doses - Single
Date:	17 June 2020
Duration:	3 Menit 46.00 detik
Type of file:	Audio MP3 (.mp3)
Audio Summary:	mp3, 44100 Hz, stereo, s16p, 128 kb/s

👉Lilac Syrup
Full Prescribing Info
Contents
Lactulose.
Description
Lilac syrup, which contains lactulose with other sugars eg, galactose and lactose, is used in the treatment of constipation and hepatic encephalopathy. Lactulose is a disaccharide, a sugar molecule composed of 2 smaller sugar molecules bonded together, in this case, fructose and galactose. Lactulose is a solid substance that is very soluble in water and has a sweet taste. It is sweeter than lactose but not as sweet as fructose. Chemically, lactulose is also known as 4-O-β-D-galactopyranosyl-D-fructofuranose. The molecular formula is C12H22O11 with a molecular weight of 342.3 daltons.
Action
Laxative.
Pharmacology: Mechanism of Action: Two mechanisms are believed to be involved in the laxative action of lactulose: First, metabolism of lactulose by bacteria results in reduced colonic pH which stimulates peristalsis and decreases stool transit time. In turn, decreased water reabsorption from the feces further facilitates the passage of soft well-formed stools. Second, increased osmotic pressure of fecal material secondary to an increase in colonic organic acids results in accumulation of fluid from surrounding tissues, helping to soften stool mass.
The therapeutic action of lactulose in ameliorating the symptoms of hepatic encephalopathy is considered to be a result of the following: Reduction of fecal pH leading to a reduced ammonia absorption via non-ionic diffusion and/or diffusion of ammonia from the blood into the gut. The trapped ammonia is then excreted in the stools; suppression of urase-producing organisms; induction of an osmotic type of diarrhea which diminishes fecal stasis with reduction of nitrogenous substances for ammonia production. Decreased absorption of ammonia from the gut also results from shortening intestinal transit time.
The actual mechanism may be a combination of these effects.
Pharmacokinetics: Absorption: Lactulose is poorly absorbed from the GIT and no enzyme capable of hydrolysis of this disaccharide is present in human GI tissue. As a result, oral doses of lactulose reach the colon virtually unchanged.
Less than 2% of lactulose is absorbed systematically. Absorption may be enhanced 4- to 6-fold by increasing the osmotic value of the intestinal contents.
Distribution: Lactulose given orally resulted in only small amounts reaching the blood.
Metabolism and Elimination: Following administration by mouth, lactulose passes essentially unchanged into the large intestine where it is metabolized by saccharolytic bacteria with the formation of simple organic acids, mainly lactic acid and small amounts of acetic and formic acids. The small amount of absorbed lactulose is subsequently excreted unchanged in the urine. Urinary excretion has been determined to be ≤3% and is essentially complete within 24 hrs.
Indications/Uses
Relief of constipation including chronic constipation. Portal systemic encephalopathy: Hepatic coma or precoma stages where hyperammonemia is present.
Dosage/Direction for Use
Constipation: Dosage can vary widely with the severity of the condition. A relatively large initial dose should be followed by a smaller maintenance dose after the first 3 days of treatment. Only 1 daily dose needs to be taken, preferably after breakfast.
Adults: Initially 15-30 mL as a single dose or in 2 divided doses. Children 5-10 years: 10 mL twice daily; ≤1-5 years: 5 mL twice daily.
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